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Protein micro- and nano-capsules for biomedical applications
Ulyana Shimanovich1, Gonçalo J L Bernardes, T P J Knowles
1Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. gb453@cam.ac.uk.
Chemical Society Reviews
|December 17, 2013
Summary
Biomacromolecules like proteins and polysaccharides can build novel micro- and nano-scale drug delivery systems. This review explores their formation, functionalization for targeted delivery, and future potential.
Area of Science:
- Biomedical Engineering
- Materials Science
- Drug Delivery
Background:
- Micro- and nano-scale systems are crucial for advanced drug delivery.
- Biomacromolecules offer versatile building blocks for these systems.
Purpose of the Study:
- To review the use of biomacromolecules (proteins, nucleic acids, polysaccharides) in creating novel drug delivery systems.
- To focus on the formation and functionalization of protein-based micro- and nano-structures for targeted delivery.
Main Methods:
- Exploration of biomacromolecule self-assembly and fabrication techniques.
- Review of functionalization strategies for targeted delivery applications.
Main Results:
- Proteins, polypeptides, nucleic acids, and polysaccharides can form micro- and nano-scale capsules and shells.
- Functionalization enables targeted delivery of bioactive materials using these structures.
Conclusions:
- Biomacromolecule-based systems present significant opportunities for innovative drug delivery.
- Further research is needed to overcome challenges and fully realize their therapeutic potential.
