Related Experiment Video

Updated: May 4, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

19.1K

[Chronic migraine]

H C Diener1, D Holle, D Müller

  • 1Universitätsklinik für Neurologie, Westdeutsches Kopfschmerzzentrum, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland, hans.diener@uni-duisburg-essen.de.

Der Nervenarzt
|December 17, 2013
PubMed

Insights

Chronic migraine, affecting 2-4% of people, significantly impacts quality of life. Proven prophylactic treatments include topiramate and onabotulinum toxin A, offering hope for managing this debilitating headache disorder.

Area of Science:

  • Neurology
  • Headache Medicine

Background:

  • The International Headache Society (IHS) classifies headaches, distinguishing between episodic and chronic forms.
  • Chronic migraine is characterized by frequent headache days (≥15/month) with migraine features for over 3 months.
  • This condition affects 2-4% of the population, leading to a compromised quality of life and increased comorbidities compared to episodic migraine.

Purpose of the Study:

  • To review the current understanding of chronic migraine, including its definition, prevalence, and impact.
  • To highlight the scarcity of data from prospective randomized studies due to patient exclusion in prior trials.
  • To summarize the proven efficacy of prophylactic treatments for chronic migraine.

Main Methods:

  • Literature review focusing on the definition and prevalence of chronic migraine.
  • Analysis of existing data regarding quality of life and comorbidity in chronic migraine patients.
  • Evaluation of evidence for prophylactic treatments based on available studies.

Main Results:

  • Chronic migraine is defined by specific headache frequency and migraine criteria.
  • Prevalence is estimated at 2-4%, with significant negative impacts on quality of life and higher comorbidity rates.
  • Prospective randomized study data for chronic migraine is limited.
  • Topiramate and onabotulinum toxin A have demonstrated efficacy compared to placebo for prophylactic treatment.

Conclusions:

  • Chronic migraine represents a significant neurological challenge with a substantial burden on patients.
  • Limited research exists, necessitating further investigation into this condition.
  • Topiramate and onabotulinum toxin A are established as effective prophylactic treatments for chronic migraine.

More Related Videos

Investigating Migraine-Like Behavior Using Light Aversion in Mice05:23

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

3.6K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

8.6K

Related Concept Videos

Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins...
20
Increased Intracranial Pressure l: Introduction01:14

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component...
27
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
906
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
26
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
41
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
900