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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Induced Pluripotent Stem Cells01:06

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Cancers Originate from Somatic Mutations in a Single Cell02:21

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Updated: May 4, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
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Aberrant DNA methylation in human cancers.

Wen Li1, Bi-Feng Chen2

  • 1Editorial Department of Journal of Clinical Surgery, Hubei Medical Association, Wuhan, 430071, China.

Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
|December 17, 2013
PubMed
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DNA methylation, an epigenetic modification, is crucial in human cancers. Recent advances in methylome analysis have improved our understanding of aberrant DNA methylation mechanisms and de-methylation drug treatments for cancer.

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Area of Science:

  • Epigenetics and Molecular Biology
  • Cancer Research
  • Genomics

Background:

  • DNA methylation is a key epigenetic mechanism involved in gene regulation.
  • Aberrant DNA methylation patterns are frequently observed in human cancers.
  • Advances in methylome analysis have accelerated cancer research.

Purpose of the Study:

  • To review recent developments in characterizing aberrant DNA methylation in human cancers.
  • To emphasize the mechanisms underlying aberrant DNA methylation in cancer development.
  • To summarize current treatment strategies using de-methylation drugs for cancer.

Main Methods:

  • Comprehensive literature review of recent studies on DNA methylation in human cancers.
  • Analysis of advancements in high-throughput methylome analysis techniques.
  • Synthesis of findings on epigenetic mechanisms and therapeutic approaches.

Main Results:

  • Significant progress has been made in understanding DNA methylation's role in various cancer types.
  • Key mechanisms driving aberrant DNA methylation in cancer are increasingly elucidated.
  • De-methylation drugs show promise as a treatment strategy for certain cancers.

Conclusions:

  • Aberrant DNA methylation is a critical factor in human cancer development.
  • Continued research into methylome analysis and epigenetic mechanisms is vital for cancer therapy.
  • De-methylation therapies represent a promising avenue for cancer treatment.