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Bora and Aurora-A continue to activate Plk1 in mitosis

Wytse Bruinsma1, Libor Macurek, Raimundo Freire

  • 1Department of Medical Oncology and Cancer Genomics Center, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.

Journal of Cell Science
|December 17, 2013
PubMed
Summary

Polo-like kinase-1 (Plk1) activation in mitosis relies on sustained Aurora-A kinase activity, with a fraction of Bora retained to maintain Plk1 phosphorylation. This ensures robust Plk1 activity for cell division.

Keywords:
Aurora-ABoraMitosisPlk1

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