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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Blood Transfusion01:15

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Structure and Function of Platelets01:18

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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Formation of the Platelet Plug01:22

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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Introduction to Hemostasis01:05

Introduction to Hemostasis

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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Microfluidics in Assessing Platelet Function
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Microfluidics in Assessing Platelet Function

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Platelet transfusion: basic aspects.

Andreas Holbro1, Laura Infanti, Jörg Sigle

  • 1Blutspendezentrum SRK beider Basel, Switzerland; andreas.holbro@usb.ch.

Swiss Medical Weekly
|December 17, 2013
PubMed
Summary
This summary is machine-generated.

Platelet transfusions save lives in patients with low platelets. Advances in preparation, pathogen reduction, and expanded uses improve treatment for hematologic cancers and drug-induced platelet issues.

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Area of Science:

  • Hematology
  • Transfusion Medicine
  • Blood Component Therapy

Background:

  • Platelet transfusions are crucial for preventing hemorrhage and improving survival in thrombocytopenic patients.
  • Significant advancements have been made in platelet component preparation, notably pathogen reduction techniques.
  • The demand for platelet components is rising due to increased treatment for hematologic-oncological diseases and expanded indications.

Purpose of the Study:

  • To review current techniques in platelet component production and storage.
  • To discuss the evolving indications for platelet transfusion.
  • To address critical safety issues, including alloimmunization and platelet refractoriness.

Main Methods:

  • Literature review of current practices in platelet component production.
  • Analysis of advancements in storage and pathogen reduction technologies.
  • Examination of clinical data and guidelines regarding transfusion indications and safety.

Main Results:

  • Current production methods emphasize safety and efficacy, incorporating pathogen reduction.
  • Indications for platelet transfusion have broadened beyond traditional thrombocytopenia.
  • Key safety concerns include alloimmunization and managing platelet refractoriness, requiring specific clinical strategies.

Conclusions:

  • Modern platelet component production and storage techniques enhance transfusion safety and efficacy.
  • Expanded indications necessitate careful consideration of patient-specific risks and benefits.
  • Addressing alloimmunization and refractoriness is vital for optimizing patient outcomes in transfusion medicine.