Related Experiment Video
Updated: May 4, 2026

07:08
Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
8.1K
Poisonous plants: effects on embryo and fetal development
Kip E Panter1, Kevin D Welch, Dale R Gardner
1USDA-Agricultural Research Service, Poisonous Plant Research Laboratory, 1150 East 1400 North, Logan, Utah, 84341.
Birth Defects Research. Part C, Embryo Today : Reviews
|December 17, 2013
Summary
Poisonous plants cause significant livestock losses and birth defects in offspring. Research focuses on identification, effects, and management strategies to mitigate these risks.
Area of Science:
- Veterinary Toxicology
- Teratology
- Agricultural Science
Background:
- Poisonous plant research initiated over a century ago due to livestock mortality.
- Key toxic plants include locoweeds, larkspurs, and water hemlock, causing substantial economic losses.
- The Poisonous Plant Research Laboratory (PPRL) has evolved to address plant identification, toxicology, and mitigation strategies.
Purpose of the Study:
- To review plants impacting embryo/fetal and neonatal development.
- To emphasize plants causing congenital malformations (birth defects).
- To provide a general overview of plant effects on developing offspring.
Main Methods:
- Literature review of poisonous plants affecting livestock and offspring.
- Focus on plants causing teratogenic effects.
- Companion paper details molecular mechanisms of toxicoses and teratogenesis.
Main Results:
- Identified numerous poisonous plants responsible for livestock poisoning and developmental abnormalities.
- Highlighted the historical and ongoing impact of toxic plants on animal agriculture.
- PPRL has become an international leader in poisonous plant research.
Conclusions:
- Understanding poisonous plants is crucial for preventing livestock losses and birth defects.
- Research contributes to both animal health and biomedical advancements.
- Effective grazing management and plant identification are key mitigation strategies.
Related Concept Videos
Teratogenicity
4.2K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.2K
Toxicity Testing in Animals
204
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
204
Toxic Reactions: Overview
4.2K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
4.2K
Types of Toxins
3.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
3.7K
Drug Toxicity: Dose-Dependent Reactions
229
Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
229
Effects of Chemicals: Overview
2.4K
Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
2.4K

