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Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

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In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
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Extracting extra-telomeric phenotypes from telomerase mouse models.

Young Hoon Sung1, Muhammad Ali, Han-Woong Lee

  • 1Department of Biochemistry, College of Life Science, and Biotechnology, Laboratory Animal Research Center, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. hwl@yonsei.ac.kr.

Yonsei Medical Journal
|December 17, 2013
PubMed
Summary
This summary is machine-generated.

Telomerase reverse transcriptase (TERT) maintains telomeres but also has extra-telomeric functions. This review examines telomerase mouse models to understand TERT's broader physiological roles beyond telomere maintenance.

Keywords:
Telomerase reverse transcriptaseanti-apoptosiscancerextra-telomeric function of TERTgenetically engineered mouseknockout mousemetabolic fitnesssenescencestem cellstransgenic

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Telomerase, composed of telomerase reverse transcriptase (TERT) and telomerase RNA, is crucial for telomere elongation and genome stability.
  • While TERT's role in telomere maintenance is established, emerging evidence highlights its non-canonical, extra-telomeric functions.
  • Understanding these diverse roles is vital for comprehending TERT's overall physiological impact.

Purpose of the Study:

  • To review telomerase mouse models and their associated phenotypes.
  • To investigate the extra-telomeric functions of telomerase reverse transcriptase (TERT).
  • To elucidate the physiological significance of TERT's non-canonical activities.

Main Methods:

  • Literature review of existing studies on telomerase mouse models.
  • Analysis of phenotypes associated with different telomerase mouse models.
  • Evaluation of evidence for TERT's extra-telomeric functions.

Main Results:

  • Diverse mouse models have been instrumental in studying telomerase's canonical role in telomere elongation.
  • Recent research indicates significant extra-telomeric functions of TERT beyond its role in telomere maintenance.
  • Phenotypic analysis of these models provides insights into the physiological consequences of TERT's non-canonical activities.

Conclusions:

  • Telomerase mouse models are valuable tools for dissecting both canonical and extra-telomeric functions of TERT.
  • Further research into these models can reveal the full scope of TERT's physiological contributions.
  • Understanding TERT's diverse roles is essential for advancing knowledge in molecular and cellular biology.