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Updated: May 4, 2026
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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
45.7K
Assessing the barriers to image-guided drug delivery
Gregory M Lanza1, Chrit Moonen, James R Baker
1Division of Cardiology, Washington University Medical School, St. Louis, MO, USA.
Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|December 17, 2013
Summary
Image-guided drug delivery (IGDD) merges medical imaging with treatment for personalized medicine. This review identifies challenges and offers recommendations to accelerate the clinical translation of IGDD technologies.
Area of Science:
- Radiological Sciences
- Nanotechnology
- Personalized Medicine
Background:
- Medical imaging is crucial for diagnosis and patient management.
- Image-guided drug delivery (IGDD) integrates imaging with therapeutic delivery for personalized medicine.
- IGDD aims to maximize treatment efficacy in diseased tissues while minimizing systemic toxicity.
Purpose of the Study:
- To discuss opportunities and challenges impacting the clinical realization of IGDD-based personalized medicine.
- To identify and address barriers limiting the clinical translation of IGDD.
- To provide recommendations for accelerating the advancement of IGDD.
Main Methods:
- Consensus opinion from a panel discussion.
- Review of existing literature on IGDD technologies.
- Identification of key barriers to clinical translation.
Main Results:
- IGDD utilizes imaging for targeted drug release and biomarker quantification.
- Significant progress has been made in IGDD technologies.
- Inadequate attention has been given to clinical translation barriers.
Conclusions:
- Accelerating the clinical translation of IGDD requires addressing identified challenges.
- Recommendations are provided to foster the advancement of IGDD.
- IGDD holds significant promise for personalized medicine and improved patient outcomes.
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