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A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
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High Fat Diet Regulation of β-Cell Proliferation and β-Cell Mass

M L Golson1, A Ackermann Misfeldt, U G Kopsombut

  • 1Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

The Open Endocrinology Journal
|December 17, 2013
PubMed
Summary

Forkhead box transcription factor FoxM1 is essential for pancreatic beta-cell proliferation in mice. This study investigates if FoxM1 is required for beta-cell replication in diet-induced obesity, a risk factor for type 2 diabetes.

Keywords:
FoxM1Obesitydiabetespancreas

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