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Related Experiment Video

Updated: May 4, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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Chorioamnionitis and subsequent lung function in preterm infants.

Marcus H Jones1, Andréa L Corso, Robert S Tepper

  • 1Institute of Biomedical Research, and School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.

Plos One
|December 17, 2013
PubMed
Summary
This summary is machine-generated.

Prenatal inflammation, known as chorioamnionitis, negatively impacts lung function in premature infants, particularly females. This effect on early life lung function highlights a sex-specific vulnerability in preterm infants exposed to inflammation.

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Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Obstetrics

Background:

  • Chorioamnionitis is a common complication of preterm birth.
  • Prenatal inflammation is increasingly recognized as a risk factor for adverse neonatal outcomes.
  • Early life lung function is a critical predictor of long-term respiratory health.

Purpose of the Study:

  • To investigate the combined effects of prematurity, gender, and chorioamnionitis on infant lung function.
  • To determine if chorioamnionitis influences lung function differently based on infant sex.
  • To assess the association between histological chorioamnionitis (HCA) and early life lung function parameters.

Main Methods:

  • Placentas from preterm deliveries (<37 weeks gestational age) were assessed for histological chorioamnionitis (HCA).
  • Infant lung function was measured in the first year of life using the Raised Volume-Rapid Thoracic Compression Technique.
  • Statistical analyses, including two-way ANOVA, were used to evaluate the relationships between HCA, sex, and lung function, adjusting for gestational age and length.

Main Results:

  • Histological chorioamnionitis (HCA) was detected in 69% of placentas from preterm infants.
  • Infants exposed to HCA had significantly lower gestational ages, higher rates of respiratory distress syndrome (RDS), early-onset sepsis, and prolonged oxygen use.
  • A significant negative trend was observed between HCA severity and lung function, with female infants exposed to HCA showing significantly lower expiratory flows compared to unexposed females; this effect was not seen in males.

Conclusions:

  • Prenatal inflammation (chorioamnionitis) has a sex-specific detrimental effect on the lung function of preterm infants.
  • Female preterm infants exposed to chorioamnionitis exhibit significantly impaired lung function.
  • These findings reinforce the link between chorioamnionitis and the development of chronic lung disease in early life.