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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

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Multiple cystic disease: K17 dysfunction?

Hugo Néstor Cabrera¹, María Daniela Hermida, Elba Griffa

¹Dermatology Department, Hospital Nacional Profesor Alejandro Posadas, Buenos Aires, Argentina.

|December 18, 2013

Summary

This study reports a rare case of steatocystoma multiplex co-occurring with multiple eccrine and apocrine hidrocystomas, eruptive syringomas, and a pilonidal cyst in a young woman.

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Area of Science:

Dermatology
Histopathology
Clinical Case Study

Background:

Multiple cutaneous adnexal tumors can present a diagnostic challenge.
Distinguishing between various cystic and papular lesions requires careful histopathological examination.

Observation:

Multiple cystic lesions (steatomas) on the neck, chest, and vulva.
Small, white facial papules diagnosed as eccrine hidrocystomas.
Blueish facial papules identified as apocrine hidrocystomas.
Eruptive syringomas on eyelids and neck, alongside facial milia.
A sacrococcygeal pilonidal cyst was also noted and removed.

Findings:

Histopathological examination confirmed steatocystoma, eccrine hidrocystoma, apocrine hidrocystoma, and syringoma.
The patient was diagnosed with steatocystoma multiplex, multiple hidrocystomas, eruptive syringomas, and a pilonidal cyst.

Implications:

This case highlights the importance of thorough histopathological examination for diagnosing multiple, distinct adnexal tumors.
Understanding the co-occurrence of these conditions aids in comprehensive patient management and genetic counseling.
Further research into the potential genetic factors or syndromes associated with this combination of skin lesions is warranted.