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Validation of a spectrophotometric assay method for bisoprolol using picric acid
Alina-Diana Panainte1, Nela Bibire, Gladiola Tântaru
1Analytical Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa" - Iaşi.
Unlabelled:
Bisoprolol is a drug belonging to beta blockers drugs used primarily for the treatment of cardiovascular diseases.
Aim:
A spectrophotometric method for quantitative determination of bisoprolol was developed based on the formation of a complex combination between bisoprolol and picric acid.
Material And Methods:
The complex combination of bisoprolol and picric acid has a maximum absorbance peak at 420 nm. Optimum working conditions were established and the method was validated.
Results:
The method presented a good linearity in the concentration range 5-120 microg/ml (regression coefficient r2 = 0.9992). The RSD for the precision of the method was 1.74 and for the intermediate precision 1.43, and recovery values ranged between 98.25-101.48%.
Conclusions:
The proposed and validated spectrophotometric method for the determination of bisoprolol is simple and cost effective.
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