Related Experiment Video
Updated: May 4, 2026
09:40
A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
Published on: January 4, 2017
19.3K
[Many dimensions of extracellular matrix research]
1Oulun yliopisto, biolääketieteen laitos.
Duodecim; Laaketieteellinen Aikakauskirja
|December 18, 2013
Summary
The extracellular matrix, or matrisome, regulates cell responses and is crucial for tissue support and bodily functions. Studying its components, like collagens, aids in developing diagnostics and treatments for genetic diseases.
Area of Science:
- Biochemistry and Molecular Biology
- Cell Biology
- Biomedical Engineering
Context:
- The extracellular matrix (ECM) provides structural support to tissues.
- ECM molecules regulate critical cellular processes including development, differentiation, and migration.
- Dysregulation of the ECM is implicated in diseases such as cancer.
Purpose:
- To highlight the multifaceted roles of the extracellular matrix in biological systems.
- To introduce the matrisome as a key component of the ECM, comprising collagens, proteoglycans, and glycoproteins.
- To emphasize the potential of understanding collagen synthesis and genetic defects for therapeutic applications.
Summary:
- The extracellular matrix (ECM) is vital for tissue structure and cellular regulation throughout life.
- The matrisome, a collection of approximately 300 ECM proteins, includes collagens, proteoglycans, and glycoproteins.
- Insights into collagen synthesis and associated gene defects offer avenues for novel diagnostic and therapeutic strategies.
Impact:
- Understanding the matrisome can lead to new approaches for treating hereditary diseases.
- Research into ECM components can improve diagnostics for various conditions.
- This knowledge supports the development of targeted therapies for diseases involving matrix dysregulation.
More Related Videos
07:28Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis
Published on: July 23, 2015
29.3K
11:51A Multi-well Format Polyacrylamide-based Assay for Studying the Effect of Extracellular Matrix Stiffness on the Bacterial Infection of Adherent Cells
Published on: July 5, 2018
13.5K
Related Concept Videos
01:42The Extracellular Matrix
65.0K
Overview
65.0K
01:29The Extracellular Matrix
10.7K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
10.7K
01:26Extracellular Matrix
5.9K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
5.9K
01:24Overview of Cell-Matrix Interactions
8.0K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
8.0K
01:13Cell-matrix's Response to Mechanical Forces
2.7K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...
Anchoring junctions mechanically attach a cell to the...
2.7K
01:23Role of Matrix Metalloproteases in Degradation of ECM
2.9K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
2.9K