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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
Evaluation of serum biomarkers IL-17 and CTX for BRONJ: a pilot clinical case-control study
Peter B Lee1, Andrew S Kiss2, Andrew L Nguyen2
1Herman Ostrow School of Dentistry, University of Southern California, USA. peterbclee@gmail.com
Abstract:
A serious complication of bisphosphonate (BP) therapy is BP-related osteonecrosis of the jaw (BRONJ). Currently, no biomarkers exist to identify patients at risk. We evaluated whether interleukin-17 and C-telopeptide correlate with BRONJ development. We conducted a case-control study using patients with a history of BP therapy. Quantitative enzyme-linked immunosorbent assay and Student's t-test were done. Both markers were significantly higher in BRONJ, suggesting altered immune responses and bone remodeling may play roles in BRONJ development.
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