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[Action of dextran-modified hyaluronidase in experimental silicosis]

O G Arkhipova, V V Iaglov, A V Maksimenko

Biulleten' Eksperimental'Noi Biologii I Meditsiny

|February 1, 1987

Abstract:

Dextran-modified hyaluronidase was inhaled or intraperitoneally injected for 4 months to mice with silicosis. Stabilized hyaluronidase was shown to have a marked inhibitory effect on the development of lung fibrosis. Drug inhalation proved to be the most effective. An antifibrotic effect of dextran itself has been observed.

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