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Updated: May 4, 2026
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Evaluation of real-time clinical decision support systems for platelet and cryoprecipitate orders
Ryan A Collins1, Darrell J Triulzi, Jonathan H Waters
1The Institute for Transfusion Medicine, 3636 Blvd of the Allies, Pittsburgh, PA 15213;
Objectives:
To evaluate cryoprecipitate and platelet ordering practices after the implementation of real-time clinical decision support systems (CDSSs) in a computerized physician order entry (CPOE) system.
Methods:
Uniform platelet and cryoprecipitate transfusion thresholds were implemented at 11 hospitals in a regional health care system with a common CPOE system. Over 6 months, a variety of information was collected on the ordering physicians and the number of alerts generated by the CDSSs when these products were ordered outside of the institutional guidelines.
Results:
There were 1,889 orders for platelets and 152 orders for cryoprecipitate placed in 6 months. Of these, 1,102 (58.3%) platelet and 74 (48.7%) cryoprecipitate orders triggered an alert. The proportion of orders canceled after an alert was generated ranged from 13.5% to 17.9% for platelets and 0% to 50.0% for cryoprecipitate orders.
Conclusions:
CDSS alerts reduce, but do not eliminate, platelet and cryoprecipitate transfusions that do not meet institutional guidelines.
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