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Heparin-binding EGF-like growth factor (HB-EGF) therapy for intestinal injury: Application and future prospects

Jixin Yang1, Yanwei Su1, Yu Zhou1

  • 1The Research Institute at Nationwide Children's Hospital, Center for Perinatal Research, Department of Pediatric Surgery, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH 43205, USA.

Pathophysiology : the Official Journal of the International Society for Pathophysiology
|December 19, 2013
PubMed

Insights

Heparin-binding EGF-like growth factor (HB-EGF) shows therapeutic potential for intestinal injuries like necrotizing enterocolitis (NEC). Studies confirm HB-EGF

Area of Science:

  • Gastroenterology and Regenerative Medicine
  • Molecular Biology and Cell Signaling

Background:

  • Heparin-binding EGF-like growth factor (HB-EGF) is a key member of the epidermal growth factor family.
  • Intestinal injuries, including necrotizing enterocolitis (NEC), ischemia/reperfusion (I/R), and hemorrhagic shock and resuscitation (HS/R), represent significant clinical challenges.

Purpose of the Study:

  • To review the therapeutic applications and protective effects of HB-EGF in established animal models of intestinal injury.
  • To emphasize the role of HB-EGF in mitigating necrotizing enterocolitis (NEC).
  • To summarize the protective mechanisms of HB-EGF on intestinal target cells.

Main Methods:

  • Review of preclinical studies investigating HB-EGF in animal models of intestinal injury.
  • Analysis of HB-EGF's demonstrated functions: mitogenic, restitution-inducing, trophic, anti-apoptotic, and vasodilatory effects.
  • Focus on HB-EGF's impact on various intestinal cell types.

Main Results:

  • HB-EGF exhibits significant protective effects across multiple models of intestinal injury.
  • Demonstrated efficacy in promoting intestinal healing and reducing cell death.
  • Identified HB-EGF as a potent factor for protecting the intestine, particularly in necrotizing enterocolitis models.

Conclusions:

  • HB-EGF possesses multifaceted therapeutic properties beneficial for intestinal injury.
  • Further clinical development of HB-EGF is warranted for treating diverse intestinal conditions, including NEC.
  • HB-EGF represents a promising therapeutic agent for gastrointestinal regenerative medicine.
Keywords:
HB-EGFHemorrhagic shockIntestinal injuryIschemia and reperfusionNecrotizing enterocolitis

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