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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

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Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
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Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
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Depression subtypes in pediatric inflammatory bowel disease.

Eva M Szigethy1, Ada O Youk, David Benhayon

  • 1*Department of Pediatric Gastroenterology, Children's Hospital of Pittsburgh †Department of Psychiatry, University of Pittsburgh School of Medicine ‡Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA §Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora ||Department of Psychiatry, Boston Children's Hospital ¶Department of Pediatric Gastroenterology, Boston Children's Hospital, Boston, MA.

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Summary

Three distinct depression profiles were identified in adolescents with inflammatory bowel disease (IBD). These findings highlight the need for tailored interventions for pediatric IBD patients experiencing somatic or cognitive depressive symptoms.

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Area of Science:

  • Pediatric Gastroenterology
  • Child and Adolescent Psychiatry
  • Psychoneuroimmunology

Background:

  • Inflammatory bowel disease (IBD) is frequently comorbid with depression in youth.
  • Understanding the relationship between systemic inflammation in IBD and depressive symptoms is crucial for effective treatment.

Purpose of the Study:

  • To identify distinct depressive symptom profiles in adolescents with comorbid IBD and depression.
  • To explore predictors of these depression profiles, including IBD activity and treatment factors.

Main Methods:

  • A cohort of 226 youth (ages 9-17) with IBD and depression underwent psychiatric and IBD assessments.
  • Latent profile analysis (LPA) was used to identify subgroups based on depressive symptom patterns.
  • Demographic, clinical, and inflammatory markers were analyzed as potential predictors of profile membership.

Main Results:

  • Three depression profiles emerged: mild (75%), somatic (19%), and cognitive (6%).
  • The somatic profile group exhibited severe fatigue and highest IBD activity, often linked to high-dose steroid use.
  • The cognitive profile group reported more anxiety and ostomy placements, with less inflammation.

Conclusions:

  • Distinct depression profiles exist in adolescents with IBD, with 25% presenting with predominantly somatic or cognitive symptoms.
  • These findings support the development of subgroup-specific interventions for depression in youth with IBD.
  • This research offers insights into the interplay of systemic inflammation and mental health in pediatric chronic illness.