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IBD across the age spectrum: is it the same disease?
Joannie Ruel1, Darren Ruane1, Saurabh Mehandru1
1Department of Medicine, Dr Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1069, New York, NY 10029, USA.
Nature Reviews. Gastroenterology & Hepatology
|December 19, 2013
Summary
Age of onset for Inflammatory Bowel Disease (IBD) influences its characteristics and natural history. Understanding these age-related differences is crucial for personalized IBD management and research.
Area of Science:
- Gastroenterology
- Immunology
- Epidemiology
Background:
- Inflammatory Bowel Disease (IBD) presents a heterogeneous clinical spectrum.
- The factors influencing the age of onset for IBD remain largely unexplained.
- Existing research suggests variations in IBD characteristics and natural history based on age at diagnosis.
Purpose of the Study:
- To review and synthesize current knowledge on age-specific differences in IBD.
- To explore variations in epidemiology, clinical presentation, and disease course across pediatric, adult, and elderly IBD populations.
- To highlight potential age-related differences in host-gene-microbial interactions in IBD.
Main Methods:
- Comprehensive literature review focusing on age-related IBD studies.
- Analysis of epidemiological data across different age groups.
- Synthesis of clinical and etiological findings stratified by age of onset.
Main Results:
- IBD exhibits distinct epidemiological patterns, clinical features, and natural histories depending on the age of onset.
- Genetic, immune, and environmental factors contributing to Crohn's disease and ulcerative colitis likely vary across the lifespan.
- Differences in host-gene-microbial interactions may contribute to age-specific IBD phenotypes.
Conclusions:
- The age of onset is a critical factor shaping IBD's etiology, phenotype, and progression.
- Recognizing age-related heterogeneity is essential for advancing IBD research and clinical practice.
- Further investigation into age-specific mechanisms is warranted for targeted therapeutic strategies.
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