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Does multiple sclerosis affect glucose tolerance?

I Wens1, U Dalgas2, N Deckx3

  • 1REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Belgium inez.wens@uhasselt.be.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|December 19, 2013
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis patients show a higher prevalence of impaired glucose tolerance (IGT) and impaired fasting glucose compared to healthy individuals. This suggests a potential link between MS and glucose metabolism abnormalities.

Keywords:
Impaired glucose tolerancediabetes type IIinsulinmultiple sclerosis

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Area of Science:

  • Neurology
  • Endocrinology
  • Metabolic Disorders

Background:

  • The relationship between multiple sclerosis (MS) and glucose metabolism, specifically impaired glucose tolerance (IGT), remains unclear in current scientific literature.
  • Investigating glucose metabolism in MS patients is crucial for understanding potential comorbidities and disease progression.

Purpose of the Study:

  • To determine if patients with multiple sclerosis (MS) have a higher risk of developing impaired glucose tolerance (IGT).
  • To compare the prevalence of IGT and impaired fasting glucose between MS patients and healthy controls.

Main Methods:

  • An oral glucose tolerance test (OGTT) was administered to 81 patients with multiple sclerosis (MS) and 45 healthy controls (HC).
  • Impaired glucose tolerance (IGT) was defined using specific fasting and two-hour post-load glucose concentration thresholds.

Main Results:

  • The prevalence of impaired fasting glucose concentrations was significantly higher in MS patients (17%) compared to HC (2%).
  • Impaired glucose tolerance (IGT) was diagnosed in 11% of MS patients, versus 0% in HC.
  • MS patients exhibited higher areas under the glucose and insulin curves during the OGTT.

Conclusions:

  • This study demonstrates an elevated prevalence of impaired glucose tolerance (IGT) in multiple sclerosis (MS) patients.
  • The findings suggest a potential link between MS and dysregulation of glucose metabolism, warranting further investigation.