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Pregabalin-induced self-harm behavior.

Vishal R Tandon1, Vivek Mahajan2, Zahid H Gillani2

  • 1Department of Pharmacology and Therapeutics, Government Medical College, Jammu, Jammu and Kashmir, India ; ADRM Centre, Government Medical College, Jammu, Jammu and Kashmir, India.

Indian Journal of Pharmacology
|December 19, 2013
PubMed
Summary
This summary is machine-generated.

Antiepileptic drugs (AEDs) may increase self-harm risk. A rare case revealed pregabalin causing self-inflicted forearm injuries after continuous use, highlighting a serious adverse drug reaction.

Keywords:
Abuse potentialdepressionpregabalinself-harmsuicidal behavior

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Clinical Toxicology

Background:

  • Antiepileptic drugs (AEDs) are commonly prescribed for epilepsy and neuropathic pain.
  • Some AEDs, including lamotrigine, gabapentin, and oxcarbazepine, have been associated with an increased risk of suicidal behavior.
  • The potential for AEDs to induce psychiatric adverse drug reactions (ADRs) warrants further investigation.

Observation:

  • This report details a rare case of self-inflicted injuries in a patient using pregabalin continuously.
  • The patient presented with multiple self-inflicted injuries on the forearm.
  • These injuries occurred following sustained use of pregabalin, a commonly prescribed AED.

Findings:

  • Pregabalin, an AED, was identified as the likely cause of the self-inflicted injuries.
  • This represents an unusual and potentially serious adverse drug reaction (ADR).
  • The case underscores the importance of monitoring for psychiatric side effects with AEDs.

Implications:

  • Clinicians should be vigilant for self-harm behaviors in patients taking AEDs, including pregabalin.
  • Further research is needed to understand the mechanisms underlying AED-induced self-harm.
  • This case highlights the need for comprehensive patient counseling regarding potential psychiatric risks of AEDs.