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Atypical B12 deficiency with nonresolving paraesthesia.

S Haider1, N Ahmad1, E J Anaissie2

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Summary
This summary is machine-generated.

Vitamin B12 deficiency can cause neurological issues. In rare cases, it may indicate POEMS syndrome, necessitating specific diagnostic tests for prompt treatment.

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Area of Science:

  • Neurology
  • Hematology
  • Endocrinology

Background:

  • Vitamin B12 deficiency presents with diverse symptoms, including neurological deficits.
  • POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes) is a rare multisystem disorder.

Purpose of the Study:

  • To report a case of an elderly female with neuropathy and vitamin B12 deficiency.
  • To highlight the association between vitamin B12 deficiency and POEMS syndrome.

Main Methods:

  • Case report of an elderly female patient.
  • Clinical presentation review.
  • Diagnostic work-up for neuropathy and vitamin B12 deficiency.

Main Results:

  • The patient presented with neuropathy and vitamin B12 deficiency.
  • Final diagnosis revealed POEMS syndrome.
  • This association is uncommon but significant.

Conclusions:

  • POEMS syndrome can manifest with vitamin B12 deficiency.
  • Consider POEMS syndrome work-up in B12-deficient patients unresponsive to standard therapy.
  • Early diagnosis of POEMS syndrome is crucial for effective management.