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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

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Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
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Pericarditis I: Introduction01:22

Pericarditis I: Introduction

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Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
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Primary Lymphoid Organs01:16

Primary Lymphoid Organs

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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
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Related Experiment Video

Updated: May 4, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

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Lupus pernio without systemic involvement.

Gopikrishnan Anjaneyan1, Rita Vora1

  • 1Department of Skin and VD, Pramukhswami Medical College, Karamsad, Gujarat, India.

Indian Dermatology Online Journal
|December 19, 2013
PubMed
Summary

Lupus pernio, a rare form of cutaneous sarcoidosis, involves facial and digit lesions. This case showed rapid improvement with topical steroids, with no systemic involvement after six years.

Area of Science:

  • Dermatology
  • Immunology
  • Rheumatology

Background:

  • Sarcoidosis is a multisystem granulomatous disease with unknown causes.
  • Exclusive cutaneous sarcoidosis is rare, often presenting as lupus pernio.
  • Lupus pernio manifests as violaceous nodules on the face and digits.

Observation:

  • A patient presented with lupus pernio.
  • The condition showed rapid improvement following topical steroid treatment.
  • The patient has been monitored for six years.

Findings:

  • Topical steroids can effectively manage lupus pernio.
  • Early-stage lupus pernio may not progress to systemic sarcoidosis.
  • Exclusive cutaneous sarcoidosis can be managed without systemic involvement.
Keywords:
Cutaneous sarcoidosisgranulomalupus pernio

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Last Updated: May 4, 2026

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Implications:

  • This case highlights the efficacy of topical steroids in treating lupus pernio.
  • It suggests that early intervention may prevent systemic progression of sarcoidosis.
  • Further research into localized sarcoidosis management is warranted.