Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.4K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.4K
Skin Cancer01:30

Skin Cancer

5.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.2K
T Cell Types and Functions01:24

T Cell Types and Functions

3.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.2K
Acne Infection01:27

Acne Infection

94
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
94
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

5.5K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
5.5K
Autoimmune Disorders01:29

Autoimmune Disorders

2.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of spesolimab for the treatment of generalized pustular psoriasis flares across pre-specified patient subgroups in the Effisayil 1 study.

Experimental dermatology·2023
Same author

Anakinra for palmoplantar pustulosis: results from a randomized, double-blind, multicentre, two-staged, adaptive placebo-controlled trial (APRICOT).

The British journal of dermatology·2021
Same author

Comparing the efficacy and tolerability of biologic therapies in psoriasis: an updated network meta-analysis.

The British journal of dermatology·2020
Same author

Risk of major cardiovascular events in patients with psoriasis receiving biologic therapies: a prospective cohort study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Secukinumab for patients failing previous tumour necrosis factor-α inhibitor therapy: results of a randomized open-label study (SIGNATURE).

The British journal of dermatology·2019
Same author

Psoriasis treat to target: defining outcomes in psoriasis using data from a real-world, population-based cohort study (the British Association of Dermatologists Biologics and Immunomodulators Register, BADBIR).

The British journal of dermatology·2019
Same journal

Dr Archibald Hewan (1832-1883) and the University of Glasgow's medical libraries.

The journal of the Royal College of Physicians of Edinburgh·2025
Same journal

An unusual case of cutaneous tuberculosis and paradoxical TB in a patient with spondyloarthritis treated with adalimumab.

The journal of the Royal College of Physicians of Edinburgh·2025
Same journal

Leptospiral infection overlapping with autoimmune hepatitis: A diagnostic conundrum.

The journal of the Royal College of Physicians of Edinburgh·2025
Same journal

Tocilizumab vs bevacizumab in critically ill COVID-19 patients: Registry-based prospective study.

The journal of the Royal College of Physicians of Edinburgh·2025
Same journal

Junior doctor medical conferences in the post-Covid era: A mixed-methods study.

The journal of the Royal College of Physicians of Edinburgh·2025
Same journal

A solitary rectal ulcer in an elderly patient.

The journal of the Royal College of Physicians of Edinburgh·2025
See all related articles

Related Experiment Video

Updated: May 4, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

38.4K

Psoriasis.

L Burfield1, A D Burden

  • 1AD Burden, Western Infirmary Dumbarton Road Glasgow G11 6NT, UK. David.Burden@glasgow.ac.uk.

The Journal of the Royal College of Physicians of Edinburgh
|December 19, 2013
PubMed
Summary
This summary is machine-generated.

Psoriasis is a chronic skin disease impacting quality of life. Management involves topical treatments, phototherapy, or systemic therapies, but long-term toxicity requires consideration alongside associated systemic conditions.

Keywords:
Psoriasisbiologic therapygeneticsphototherapypsoriatic arthritistopical therapy

More Related Videos

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

1.1K
SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments
06:34

SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments

Published on: August 8, 2025

676

Related Experiment Videos

Last Updated: May 4, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

38.4K
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

1.1K
SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments
06:34

SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments

Published on: August 8, 2025

676

Area of Science:

  • Dermatology
  • Immunology
  • Public Health

Background:

  • Psoriasis is a chronic, immune-mediated skin disease affecting 1.3-2.2% of the UK population.
  • Characterized by red, scaly plaques, it significantly impairs quality of life, comparable to major diseases like cancer.
  • Beyond skin manifestations, psoriasis is linked to systemic conditions including psoriatic arthritis, inflammatory bowel disease, cardiovascular disease, and metabolic syndrome.

Purpose of the Study:

  • To outline the assessment and management of psoriasis.
  • To highlight the importance of monitoring for systemic comorbidities.
  • To inform healthcare providers about current guidelines and therapeutic options.

Main Methods:

  • Review of current therapeutic modalities for psoriasis.
  • Analysis of established and emerging systemic manifestations.
  • Consideration of guidelines from NICE and SIGN for patient assessment.

Main Results:

  • Psoriasis requires a multi-faceted management approach, from topical treatments to advanced therapies like biologics.
  • Effective treatments exist, but potential long-term toxicities necessitate careful monitoring.
  • Systemic comorbidities such as psoriatic arthritis, cardiovascular disease, and metabolic syndrome are increasingly recognized and require regular assessment.

Conclusions:

  • Comprehensive management of psoriasis must include monitoring for and addressing systemic comorbidities.
  • Regular assessment for conditions like arthritis, obesity, diabetes, and hypertension is crucial.
  • Adherence to updated guidelines (NICE, SIGN) ensures optimal patient care and detection of associated health risks.