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The challenges in moving from ageing to successful longevity
Genovefa Kolovou, Nir Barzilai, Calogero Caruso
1Onassis Cardiac Surgery Center, 356 Sygrou Ave 176 74 Athens, Greece. genovefa@kolovou.com.
Current Vascular Pharmacology
|December 20, 2013
Summary
Centenarians are a growing population, with lifespan influenced by genetics, lifestyle, and healthcare. Research explores factors contributing to exceptional longevity and health in the oldest old.
Area of Science:
- Gerontology and genetics
- Human longevity research
Background:
- Increasing number of centenarians globally.
- Lifespan influenced by genetic (approx. 25%) and environmental factors.
- Lifestyle and healthcare improvements contribute to increased human lifespan.
Purpose of the Study:
- Investigate factors contributing to reaching 100 years.
- Compare health and functional status of centenarians versus younger deceased individuals.
- Explore genetic, epigenetic, and nutrigenomic influences on longevity.
- Assess benefits of medical treatments and drug research for longevity.
Main Methods:
- Review of existing literature on centenarian studies.
- Analysis of factors influencing lifespan variation.
- Exploration of definitions for successful and exceptional aging.
Main Results:
- Lifespan is multifactorial, involving genetics, lifestyle, and environment.
- Centenarians may exhibit better health and functional maintenance.
- Further research is needed to understand specific longevity mechanisms.
Conclusions:
- Understanding centenarian characteristics is key to promoting healthy aging.
- Distinguishing between 'Longevity Syndrome' and 'Exceptional Longevity' is important.
- Future research should focus on actionable interventions for extending healthspan.
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