Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anorexia Nervosa01:28

Anorexia Nervosa

2.0K
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
2.0K
Bulimia Nervosa01:30

Bulimia Nervosa

1.1K
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
1.1K
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

1.1K
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
1.1K
Overview of Protein Metabolism01:21

Overview of Protein Metabolism

4.5K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
4.5K
Metabolic States of the Body: Fasting and Starvation01:24

Metabolic States of the Body: Fasting and Starvation

2.8K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
2.8K
Binge Eating Disorders01:23

Binge Eating Disorders

828
Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
828

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oral and Vaginal Probiotics and Pregnancy Outcomes in Women With Infertility: A Systematic Review and Meta-analysis.

Obstetrics and gynecology·2026
Same author

Time-restricted eating versus dietetic guidance on glycaemic outcomes in adults at risk of type 2 diabetes: a non-inferiority randomised clinical trial.

Diabetologia·2026
Same author

Exploring the impact of intermittent fasting plus time-restricted eating versus calorie restriction on eating behavior, mood, sleep, quality of life in adults with obesity.

Clinical nutrition (Edinburgh, Scotland)·2026
Same author

Ketone Profiles in Community-Dwelling Adults with Type 1 Diabetes Using Continuous Ketone Monitoring.

Diabetes technology & therapeutics·2026
Same author

Survey of glucose levels in adults with T1DM attending clinic using automated insulin delivery (AID) devices compared with manual insulin delivery.

Diabetes research and clinical practice·2026
Same author

Moderate intake of bitter foods is associated with lower risk of type 2 diabetes: A secondary analysis of the 2011-12 National Nutrition and Physical Activity Survey.

Nutrition research (New York, N.Y.)·2026
Same journal

Fish oil and evening primrose oil have ameliorative effects on obesity-associated complications in olanzapine-administered rats.

Obesity research & clinical practice·2026
Same journal

Adolescent body mass index as a strong predictor of pre-pregnancy obesity in Arkansas mothers.

Obesity research & clinical practice·2026
Same journal

A body shape index is a better predictor of overall and cardiovascular mortality than body mass index: Results from the ENAH study.

Obesity research & clinical practice·2026
Same journal

The case to augment healthcare professional training for the treatment of obesity by integrating cognitive dissonance interventions to reduce weight stigma.

Obesity research & clinical practice·2026
Same journal

Nrf2 in obesity: Mechanisms, models, and bioactive modulators.

Obesity research & clinical practice·2026
Same journal

Interpretable machine learning and incremental prognostic model for all-cause and cardiovascular mortality in obesity with MASLD population: Comorbidity insights from triglyceride-glucose and its obesity-related derivatives.

Obesity research & clinical practice·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Assessing Activity-based Anorexia in Mice
08:26

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

11.7K

Metabolic dysfunction in anorexia nervosa.

Leonie K Heilbronn1, Kerry-Lee Milner1, Adamandia Kriketos1

  • 1Diabetes and Obesity Research Program, Garvan Institute for Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia.

Obesity Research & Clinical Practice
|December 20, 2013
PubMed
Summary
This summary is machine-generated.

Women with anorexia nervosa (AN) show altered metabolic responses to glucose and exercise, despite appearing metabolically healthy at rest. Further research is needed to understand weight gain impediments in AN.

More Related Videos

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
07:46

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

15.2K
A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis
04:19

A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis

Published on: May 10, 2022

5.7K

Related Experiment Videos

Last Updated: May 4, 2026

Assessing Activity-based Anorexia in Mice
08:26

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

11.7K
Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
07:46

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

15.2K
A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis
04:19

A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis

Published on: May 10, 2022

5.7K

Area of Science:

  • Metabolic Medicine
  • Endocrinology
  • Nutritional Science

Background:

  • Anorexia nervosa (AN) is a severe eating disorder characterized by self-induced energy deficit and low body weight.
  • AN has significant consequences for multiple organ systems and a tendency to perpetuate itself.

Purpose of the Study:

  • To compare metabolic responses to glucose and exercise in women with AN before and after a weight gain program.
  • To compare these responses with those of lean, healthy weight women.

Main Methods:

  • Compared 10 women with AN and 7 healthy controls.
  • Assessed weight, body composition, and indirect calorimetry.
  • Measured serum insulin, glucose, adiponectin, and leptin responses to oral glucose and cycling exercise.

Main Results:

  • AN patients had less body fat but similar lean mass compared to controls.
  • AN patients exhibited higher adiponectin and lower leptin levels.
  • Exercise increased fasting glucose in AN patients, unlike controls; a trend towards increased diet-induced thermogenesis was observed post-glucose in AN.

Conclusions:

  • AN patients display altered metabolic responses to physiological stressors despite appearing metabolically healthy at rest.
  • Impediments to weight gain in AN require further investigation to enhance nutritional management effectiveness.