Clinical and experimental observations of peripheral blood leukocytes and nucleated bone marrow cells after local irradiation

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X G Zhang¹, A N Du, C Geng

¹Department of Hematology, Jiangsu University Affiliated Xuzhou Hospital (Xuzhou Tumor Hospital), Xuzhou, China - zxgjh1992@qq.com.

|December 20, 2013

Abstract

Aim:

Aim of the study was to observe the impact of bone marrow damage induced by local irradiation on leukopenia.

Methods:

For the human study, five cancer patients received local radiation therapy. Bone marrow aspiration was conducted to measure nucleated cell count and 99mTc-Sc sulfur colloid ECT imaging was carried out to examine bone marrow function. For the animal study, fifty New Zealand white rabbits were divided into 3 groups: non-irradiated control group (N.=10), abdomen irradiation group (irradiation area did not cover bone marrow) (N.=20), chest irradiation group (irradiation area covered bone marrow) (N.=20). Nucleated cell counts were taken after confirming onset of leukopenia.

Results:

Bone marrow of five patients proliferated normally. ECT imaging showed no abnormality in the pattern of red bone marrow distribution. Hematopoietic function was mildly active.

Conclusion:

Suppressed myeloproliferative function does not fully account for irradiation-induced leukopenia.

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