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Published on: July 21, 2014
Two-component systems in Streptomyces: key regulators of antibiotic complex pathways
Héctor Rodríguez, Sergio Rico, Margarita Díaz
1Instituto de Biología Funcional y Genómica (IBFG)/Departamento de Microbiología y Genética, Consejo Superior de Investigaciones Científicas (CSIC)/Universidad de Salamanca, C/ Zacarías González, n° 2, 37007 Salamanca, Spain. santa@usal.es.
Abstract:
Streptomyces, the main antibiotic-producing bacteria, responds to changing environmental conditions through a complex sensing mechanism and two-component systems (TCSs) play a crucial role in this extraordinary "sensing" device.Moreover, TCSs are involved in the biosynthetic control of a wide range of secondary metabolites, among them commercial antibiotics. Increased knowledge about TCSs can be a powerful asset in the manipulation of bacteria through genetic engineering with a view to obtaining higher efficiencies in secondary metabolite production. In this review we summarise the available information about Streptomyces TCSs, focusing specifically on their connections to antibiotic production.
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