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Cyclodextrin inclusion complexes loaded in particles as drug carrier systems
Leonardo Fernandes Fraceto, Renato Grillo, Eduardo Sobarzo-Sánchez1
1Departamento de Engenharia Ambiental, Universidade Estadual Paulista, Av. Tres de Marco, 511, Sorocaba, SP, 18087-180, Brazil. leonardo@sorocaba.unesp.br.
Current Topics in Medicinal Chemistry
|December 21, 2013
Summary
This review explores advanced drug delivery systems combining cyclodextrins with liposomes and nanoparticles. These hybrid systems show promise for enhanced pharmaceutical delivery and therapeutic applications.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Nanotechnology
Background:
- Cyclodextrins are widely used for pharmaceutical complexation.
- Classical cyclodextrin-pharmaceutical interactions are well-established.
- Emerging research focuses on integrating cyclodextrins with other nanocarriers.
Purpose of the Study:
- To review recent advancements in hybrid host:guest drug delivery systems.
- To highlight the integration of cyclodextrin complexes with liposomes and nanoparticles.
- To showcase the state-of-the-art in advanced drug carrier development.
Main Methods:
- Literature review of recent scientific reports.
- Analysis of studies on combined cyclodextrin-based systems.
- Examination of developed liposomal and nanoparticle formulations.
Main Results:
- Demonstration of successful association between cyclodextrin complexes and nanocarriers.
- Examples of novel drug delivery systems incorporating these strategies.
- Identification of advantages offered by these hybrid systems.
Conclusions:
- Hybrid cyclodextrin-liposome and cyclodextrin-nanoparticle systems represent a significant advancement.
- These integrated systems offer enhanced potential as sophisticated drug carriers.
- The reviewed strategies pave the way for next-generation pharmaceutical formulations.
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