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Association study of angiotensin converting enzyme gene polymorphism with elderly diabetic hypertension and lipids
Yun-Fei Zhou, Hui Yan, Xiao-Ping Hou
1The cadre ward of General Hospital of the Air Force PLA, No, 30, Fucheng Road, Haidian District, Beijing 100142, China. luohuilan998@163.com.
Objective:
To investigate the relationship between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and diabetic essential hypertension in elderly population.
Methods:
Polymerase chain reaction (PCR) technique was used in 260 elderly normal control patients, 205 elderly hypertensive patients and 138 elderly diabetic hypertensive patients to detect the I/D polymorphism in ACE gene.
Results:
DD genotype frequency (0.352) and D allele frequency (0.543) in elderly hypertensive patients were higher than those in the normal control patients. DD genotype (0.421) and D allele frequency (0.579) in elderly diabetic hypertensive patients were significantly higher than those in the control patients (0.133 and 0.250). The differences of DD genotype and D allele frequency between the elderly hypertensive patients and the elderly diabetic hypertensive patients were not significant (P > 0.05).
Conclusion:
ACE gene deletion is a risk factor for hypertension but is not a risk factor for diabetes in elderly population.
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