Related Experiment Video
Updated: May 4, 2026
OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery
Published on: May 9, 2021
Progesterone level at oocyte retrieval predicts in vitro fertilization success in a short-antagonist protocol: a
Shweta Nayak1, Melanie E Ochalski2, Bo Fu3
1Magee-Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Magee-Women's Research Institute, Pittsburgh, Pennsylvania.
Objective:
To evaluate the distribution of P levels on the day of oocyte retrieval as it relates to pregnancy outcome in an antagonist protocol, which may be at higher risk for elevated P levels.
Design:
Prospective cohort study.
Setting:
Academic IVF center.
Patient(S):
One hundred eighty-six women undergoing controlled ovarian hyperstimulation with an antagonist protocol.
Intervention(S):
None.
Main Outcome Measure(S):
Implantation, pregnancy, and spontaneous abortion rates were collected.
Result(S):
Implantation rate (positive hCG 14 days after ET) and pregnancy rate were significantly higher when the P level was <12 ng/mL on the day of oocyte retrieval. Miscarriage rates were higher when the P level was ≥12 ng/mL, although this did not reach statistical significance.
Conclusion(S):
Elevated P on the day of oocyte retrieval is associated with significantly lower implantation and ongoing pregnancy rates. This is the first study to date to both uncover the distribution of P on the day of oocyte retrieval in an antagonist cycle and determine the impact an elevation may have on pregnancy outcome.
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