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Facile Preparation of 4-Substituted Quinazoline Derivatives
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4-Thiazolidinones: the advances continue….

Avinash C Tripathi1, Shiv Ji Gupta1, Gul Naz Fatima1

  • 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Babu Banarasi Das Northern India Institute of Technology, BBD City, Faizabad Road, Lucknow 226028, U.P., India.

European Journal of Medicinal Chemistry
|December 21, 2013
PubMed
Summary
This summary is machine-generated.

This review highlights recent advancements in 4-thiazolidinone chemistry and biological activities. It covers new synthetic strategies and patent information, focusing on research published after 2006.

Keywords:
AnticancerAnticonvulsantAntidiabeticAntihyperlipidemicAntimicrobialAntiparasiticAntituberculosisAntiviralCardiovascularNSAIDPatents on 4-thiazolidinonesStereochemistrySynthesis and characterizationThiazolidin-4-ones

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Area of Science:

  • Medicinal Chemistry
  • Organic Synthesis
  • Pharmacology

Background:

  • 4-Thiazolidinones exhibit diverse biological responses, attracting significant research interest.
  • Developing novel synthetic strategies requires up-to-date knowledge of recent advancements.
  • Previous reviews may not cover the latest progress in the field.

Purpose of the Study:

  • To provide a comprehensive overview of 4-thiazolidinone chemistry and biological activities.
  • To focus on research published predominantly after 2006, highlighting recent progress.
  • To include an analysis of patents related to 4-thiazolidinone derivatives.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of patent databases (WIPO and USPTO).
  • Focus on research published from 2000 to 2012, with emphasis post-2006.

Main Results:

  • Significant progress in the synthesis of novel 4-thiazolidinone derivatives.
  • Identification of diverse biological activities associated with these compounds.
  • Overview of patent landscape for 4-thiazolidinones, indicating commercial interest.

Conclusions:

  • 4-Thiazolidinones remain a promising scaffold for drug discovery.
  • Continued research is essential for developing new therapeutic agents.
  • Patent analysis reveals ongoing innovation and potential applications.