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4-Thiazolidinones: the advances continue….
Avinash C Tripathi1, Shiv Ji Gupta1, Gul Naz Fatima1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Babu Banarasi Das Northern India Institute of Technology, BBD City, Faizabad Road, Lucknow 226028, U.P., India.
European Journal of Medicinal Chemistry
|December 21, 2013
Summary
This review highlights recent advancements in 4-thiazolidinone chemistry and biological activities. It covers new synthetic strategies and patent information, focusing on research published after 2006.
Area of Science:
- Medicinal Chemistry
- Organic Synthesis
- Pharmacology
Background:
- 4-Thiazolidinones exhibit diverse biological responses, attracting significant research interest.
- Developing novel synthetic strategies requires up-to-date knowledge of recent advancements.
- Previous reviews may not cover the latest progress in the field.
Purpose of the Study:
- To provide a comprehensive overview of 4-thiazolidinone chemistry and biological activities.
- To focus on research published predominantly after 2006, highlighting recent progress.
- To include an analysis of patents related to 4-thiazolidinone derivatives.
Main Methods:
- Literature review of scientific publications.
- Analysis of patent databases (WIPO and USPTO).
- Focus on research published from 2000 to 2012, with emphasis post-2006.
Main Results:
- Significant progress in the synthesis of novel 4-thiazolidinone derivatives.
- Identification of diverse biological activities associated with these compounds.
- Overview of patent landscape for 4-thiazolidinones, indicating commercial interest.
Conclusions:
- 4-Thiazolidinones remain a promising scaffold for drug discovery.
- Continued research is essential for developing new therapeutic agents.
- Patent analysis reveals ongoing innovation and potential applications.
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