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Updated: May 4, 2026

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
Published on: January 19, 2019
Inflammatory pathways of seizure disorders
Nicola Marchi1, Tiziana Granata2, Damir Janigro3
1Department of Molecular Medicine, Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA; Department of Neurobiology, Institute of Functional Genomics, Centre National de la Recherche Scientifique, Montpellier, France.
Abstract:
Epilepsy refers to a cluster of neurological diseases characterized by seizures. Although many forms of epilepsy have a well-defined immune etiology, in other forms of epilepsy an altered immune response is only suspected. In general, the hypothesis that inflammation contributes to seizures is supported by experimental results. Additionally, antiepileptic maneuvers may act as immunomodulators and anti-inflammatory therapies can treat seizures. Triggers of seizure include a bidirectional communication between the nervous system and organs of immunity. Thus, a crucial cellular interface protecting from immunological seizures is the blood-brain barrier (BBB). Here, we summarize recent advances in the understanding and treatment of epileptic seizures that derive from a non-neurocentric viewpoint and suggest key avenues for future research.
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