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Updated: May 4, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
[The obsessive compulsive disorder]
João Flores Alves Dos Santos1, Luc Mallet2
1Service de psychiatrie de liaison et intervention crise, hôpitaux universitaires de Genève (HUG), Genève, Suisse - Équipe BEBG (behavior, emotion and basal ganglia), Institut du cerveau et de la moelle épinière (ICM), hôpital Pitié-Salpêtrière, 47, boulevard de l'Hôpital, 75013 Paris, France.
Abstract:
The obsessive compulsive disorder (OCD) is a frequent disease with a high comorbidity. The usual treatment is a combination of pharmacological and psychotherapeutic treatment. However, 30% of patients still have persistent and severe symptoms, with an important functional impact. These last years, the integration of the new neuroanatomical, neurochemical, neuropsychological, genetic and phenomenological data, allows a better understanding of the physiopathology and the development of new treatments for OCD, as neuromodulation for the severe and refractory cases.
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