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Related Experiment Video

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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Perinatal mortality and advanced maternal age.

Irene Mutz-Dehbalaie1, Matthias Scheier, Susanne Jerabek-Klestil

  • 1Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria.

Gynecologic and Obstetric Investigation
|December 21, 2013
PubMed
Summary

Advanced maternal age, particularly over 40, increases stillbirth risk. Obesity and inadequate antenatal care are key modifiable factors impacting perinatal outcomes.

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Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Medicine
  • Reproductive Health

Background:

  • Advanced maternal age (AMA) is increasingly common.
  • The impact of AMA on perinatal mortality requires ongoing investigation.

Purpose of the Study:

  • To investigate the impact of advanced maternal age on perinatal mortality rates.
  • To identify modifiable risk factors associated with perinatal mortality in older mothers.

Main Methods:

  • Retrospective cohort study of 56,517 singleton deliveries (1999-2008).
  • Maternal age categorized into 3 groups: 25-34 years (reference), 35-39 years, and ≥ 40 years.
  • Analysis included odds ratios (ORs) for antenatal and neonatal deaths, and adjusted ORs for perinatal mortality.

Main Results:

  • Women aged ≥ 40 years had a significantly increased risk of stillbirth (OR = 2.57).
  • Adjusted analysis showed an increased risk of perinatal mortality for women ≥ 40 years (aOR = 1.66).
  • Poor antenatal care ( <4 visits) and obesity were significant, modifiable risk factors for perinatal mortality in older age groups.

Conclusions:

  • Women aged 40 and over face a higher risk of stillbirth.
  • Obesity and insufficient antenatal care are critical, addressable factors contributing to adverse perinatal outcomes in advanced maternal age pregnancies.