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Vascular endothelial growth factor and insulin-like growth factor-1 in preterm infants with retinopathy of

Ali Peirovifar1, Manizheh Mostafa Gharehbaghi1, Parvin Mostafa Gharabaghi1

  • 1Neonatal Intensive Care Unit, Al Zahra Hospital, South Arthesh Street, 513866449, Tabriz, Iran. gharehbaghimm@yahoo.com.

Singapore Medical Journal
|December 21, 2013
PubMed

Insights

This study found no significant difference in blood vascular endothelial growth factor (VEGF) or insulin-like growth factor-1 (IGF-1) levels between premature infants with retinopathy of prematurity (ROP) and those without. These findings suggest these specific biomarkers may not be useful indicators for ROP in this age group.

Area of Science:

  • Neonatal Medicine
  • Ophthalmology
  • Biochemistry

Background:

  • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
  • Understanding the biochemical factors involved in ROP is crucial for early detection and intervention.

Purpose of the Study:

  • To investigate the levels of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) in premature infants with proliferative ROP.
  • To compare these levels with those in premature infants without ROP.

Main Methods:

  • Blood samples were collected from 71 preterm infants (born ≤32 weeks gestation) 6-8 weeks after birth.
  • Infants were categorized into a control group (no ROP) and a study group (proliferative ROP, stage III+).
  • VEGF and IGF-1 levels were quantified using enzyme-linked immunosorbent assay (ELISA).

Main Results:

  • No significant differences in mean blood IGF-1 levels were observed between the ROP group (18.48 ± 11.79 µg/L) and the control group (16.75 ± 13.74 µg/L).
  • Similarly, mean blood VEGF levels did not differ significantly between the ROP group (267.35 ± 103.43 pg/mL) and the control group (237.52 ± 130.92 pg/mL).
  • Gestational age and postmenstrual age at sampling were comparable between the groups.

Conclusions:

  • Blood IGF-1 and VEGF levels at 6-8 weeks postpartum are not significantly different in premature infants with proliferative ROP compared to those without.
  • These biomarkers may not serve as reliable indicators for diagnosing or assessing the severity of ROP at this stage.
Abstract

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