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Measuring Lactase Enzymatic Activity in the Teaching Lab
Published on: August 6, 2018
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A diagnostic approach to patients with suspected lactose malabsorption
Tsachi Tsadok Perets1, Einav Shporn, Shoshana Aizic
1Laboratory of Gastroenterology, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.
Digestive Diseases and Sciences
|December 21, 2013
Summary
The lactose breath test (LBT) is a less sensitive screening tool for lactose malabsorption than the lactose intolerance quick test (LIQT). Patients with negative LBT results but symptoms should undergo LIQT testing.
Area of Science:
- Gastroenterology
- Diagnostic Medicine
Background:
- The lactose breath test (LBT) is the standard for diagnosing lactose malabsorption but has limitations.
- The lactose intolerance quick test (LIQT) assesses lactase activity via duodenal biopsies.
Purpose of the Study:
- To evaluate the diagnostic roles of LBT and LIQT in suspected lactose malabsorption.
- To compare the effectiveness of LBT and LIQT in patient management.
Main Methods:
- 69 patients with suspected lactose malabsorption underwent both LBT and LIQT.
- Sensitivity, specificity, and predictive values of the LBT were calculated.
- LIQT results were compared against LBT findings.
Main Results:
- LIQT identified hypolactasia in 80% of patients (mild 25%, severe 75%).
- LBT detected lactose malabsorption in only 46% of patients.
- A significant number (65%) of patients with normal LBT results showed positive LIQT findings.
Conclusions:
- LBT can be used as an initial screening tool for lactose malabsorption.
- Symptomatic individuals with negative LBT results require further investigation with LIQT.
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