Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

9.1K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.1K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

6.1K
6.1K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

4.8K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.8K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

8.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.3K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

2.6K
2.6K
Abnormal Proliferation02:23

Abnormal Proliferation

4.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Primary study on origination of bone marrow abnormal clones in patients with myelodysplastic syndrome].

Zhongguo shi yan xue ye xue za zhi·2011
Same author

Clinical management of gastric cancer: results of a multicentre survey.

BMC cancer·2011
Same author

[Surveys on resources and varieties on Chinese markets of crude drug mahuang].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2011
Same author

Synthesis of 1,5-benzothiazepine derivatives bearing 2-phenoxy-quinoline moiety via 1,3-diplolar cycloaddition reaction.

Molecular diversity·2011
Same author

Three-dimensional magnetic assembly of microscale hydrogels.

Advanced materials (Deerfield Beach, Fla.)·2011
Same author

The assembly of cell-encapsulating microscale hydrogels using acoustic waves.

Biomaterials·2011
Same journal

IL-17-driven tumor cell-intrinsic inflammatory programming creates an immunotherapy-permissive microenvironment.

Molecular cancer·2026
Same journal

Dissecting oral premalignant carcinogenesis: spatial omics mechanisms and nanomedicine-driven therapeutic innovation.

Molecular cancer·2026
Same journal

A plasma proteomic signature of cancer-related sarcopenia implicates the IGFBP axis in muscle dysfunction.

Molecular cancer·2026
Same journal

The role of the WD40-repeat protein family in cancer.

Molecular cancer·2026
Same journal

Correction: Glioblastoma multiforme: insights into pathogenesis, key signaling pathways, and therapeutic strategies.

Molecular cancer·2026
Same journal

Antibody-drug conjugates in breast cancer: from mechanism to revolutionizing clinical practice.

Molecular cancer·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

978

CHD1L: a novel oncogene.

Wen Cheng1, Yun Su, Feng Xu

  • 1Department of Urology, Nanjing Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu, P,R, of China. Dr_Chengwen@126.com.

Molecular Cancer
|December 24, 2013
PubMed
Summary
This summary is machine-generated.

The chromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L) is an oncogene amplified in solid tumors. It drives cancer progression by promoting cell proliferation and inhibiting apoptosis, serving as a potential biomarker and therapeutic target.

More Related Videos

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

7.7K
Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
12:04

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Published on: March 10, 2023

6.1K

Related Experiment Videos

Last Updated: May 4, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

978
HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

7.7K
Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
12:04

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Published on: March 10, 2023

6.1K

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Genomic sequencing has identified numerous cancer driver genes, but many require further investigation.
  • CHD1L (chromodomain helicase/ATPase DNA binding protein 1-like gene), also known as ALC1, is an oncogene located at Chr1q21 and frequently amplified in solid tumors.

Purpose of the Study:

  • To investigate the oncogenic role and underlying mechanisms of CHD1L in tumorigenesis.
  • To evaluate CHD1L as a potential biomarker for cancer progression and prognosis.

Main Methods:

  • Functional studies in hepatocellular carcinoma and other tumor models.
  • Analysis of CHD1L's interaction with apoptotic proteins (e.g., Nur77) and signaling pathways (e.g., AKT).
  • Examination of CHD1L-mediated target gene expression.

Main Results:

  • CHD1L promotes tumorigenesis by enhancing cell proliferation and G1/S transition, while inhibiting apoptosis.
  • Mechanisms include binding to Nur77 and activating the AKT pathway via target genes like ARHGEF9, SPOCK1, and TCTP.
  • CHD1L is identified as an independent biomarker for progression, prognosis, and survival in several solid tumors.

Conclusions:

  • CHD1L plays a significant oncogenic role in various solid tumors.
  • Understanding CHD1L's function provides a basis for developing targeted therapies.
  • CHD1L serves as a promising biomarker for clinical outcomes in cancer patients.