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Protective effect of turmeric extract on ethotrexate-induced intestinal damage and oxidative stress

Adel Rezaei Moghadam1, Daryoush Mohajeri2, Ali Namvaran-Abbas-Abad3

  • 1Young Researchers Club, Ardabil Branch, Islamic Azad University, Ardabil, Iran; Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran.

Chinese Journal of Natural Medicines
|December 24, 2013
PubMed
Abstract

Insights

Turmeric extract may protect the small intestine from methotrexate damage by reducing oxidative stress. This study found that turmeric significantly improved antioxidant levels and reduced intestinal damage in rats treated with methotrexate.

Area of Science:

  • Pharmacology and Toxicology
  • Gastroenterology
  • Natural Product Research

Background:

  • Methotrexate (MTX) is a widely used chemotherapy agent with mucositis as a significant side effect.
  • Oxidative stress plays a crucial role in MTX-induced intestinal damage.

Purpose of the Study:

  • To investigate the protective effects of turmeric extract against MTX-induced intestinal injury in a rat model.
  • To evaluate the impact of turmeric on oxidative stress markers in MTX-treated rats.

Main Methods:

  • Male Wistar albino rats were divided into six groups, receiving varying doses of turmeric extract and/or MTX.
  • Biochemical analyses included total antioxidant status (TAS), glutathione peroxidase (GPx), superoxidase dismutase (SOD), catalase (CAT), and malondialdehyde (MDA).
  • Histopathological examination of jejunum tissues assessed MTX-induced intestinal damage.

Main Results:

  • MTX treatment led to severe intestinal damage, including villus shortening, inflammation, and necrosis.
  • MTX significantly decreased SOD, GPx, and CAT levels, while increasing lipid peroxidation.
  • Turmeric extract administration, especially in combination with MTX, significantly increased antioxidant enzyme levels and reduced lipid peroxidation.

Conclusions:

  • Turmeric extract demonstrates significant protective effects on the small intestine against MTX-induced damage.
  • The antioxidant properties of turmeric are likely responsible for its protective mechanism.
  • Turmeric extract shows potential as a therapeutic agent to mitigate MTX-induced gastrointestinal toxicity.
Keywords:
Intestinal damageMethotrexateOxidative stressTurmeric

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