Membranous nephropathy with acquired factor V inhibitor: a case report

Area of Science:

• Nephrology
• Hematology
• Immunology

Background:

• Membranous nephropathy is a leading cause of nephrotic syndrome in adults.
• Acquired factor V inhibitors represent a rare bleeding disorder.

Observation:

• A 62-year-old male with a history of bleeding and hyper immunoglobulin E syndrome presented with proteinuria.
• Diagnosis revealed acquired factor V inhibitors and membranous nephropathy with glomerular endothelial damage.

Findings:

• The patient's coagulation tests and proteinuria improved following steroid administration.
• Glomerular endothelial damage was noted, a feature implicated in other factor disorders.

Implications:

• This case suggests a potential link between factor V inhibitors and the pathogenesis of membranous nephropathy.
• Further research may elucidate the mechanisms connecting these two conditions.