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Related Experiment Video

Updated: May 4, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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Persistent organ dysfunction after severe sepsis: a systematic review.

Faheem W Guirgis1, Jay D Khadpe2, Gretchen M Kuntz3

  • 1University of Florida College of Medicine, Jacksonville, Department of Emergency Medicine, Jacksonville, FL, USA.

Journal of Critical Care
|December 24, 2013
PubMed
Summary
This summary is machine-generated.

Survivors of severe sepsis experience significant organ dysfunction one month post-infection, with rates varying widely across studies. More research is needed to understand long-term organ dysfunction and develop preventative treatments.

Keywords:
Long-term organ dysfunctionLong-term outcomesOrgan dysfunctionOrgan failureSepsis survivalSeptic shockSevere sepsis

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Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Nephrology
  • Pulmonology
  • Hepatology
  • Neurology

Background:

  • Sepsis is a life-threatening condition with high mortality rates.
  • Survivors often face long-term health issues, including organ dysfunction.
  • Limited data exists on persistent organ dysfunction after severe sepsis.

Purpose of the Study:

  • To systematically review research on organ-specific outcomes in severe sepsis survivors.
  • To evaluate organ dysfunction at 28 days or longer post-sepsis.

Main Methods:

  • Systematic review of original research studies.
  • Inclusion criteria focused on organ-specific outcomes at ≥28 days in severe sepsis survivors.

Main Results:

  • Five studies met inclusion criteria; none reported outcomes beyond 30 days.
  • One-month organ dysfunction rates varied: ARDS (8-9%), renal (7-8%), hepatic (3-7%), CNS (2-5%).
  • The most recent study reported over 47% dysfunction across all organ systems; resolution rates were variable.

Conclusions:

  • Significant variability exists in organ dysfunction rates one month after severe sepsis.
  • Further research is crucial to define long-term organ dysfunction (beyond one month) and identify preventative strategies.
  • Standardized outcome measures are needed for comparable future studies.