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A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
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Carotid stenting versus endarterectomy cognitive outcomes
Oliveira Germano da Paz1, Ana Terezinha Guillaumon1, Tátila Martins Lopes2
1Department of Surgery, University of Campinas, Sao Paulo, Brazil.
Annals of Vascular Surgery
|December 24, 2013
Summary
Carotid revascularization improved cognitive function in patients undergoing carotid artery stenting (CAS) or carotid endarterectomy (CEA). The CAS group showed particular gains in executive functions and working memory.
Area of Science:
- Neurology
- Vascular Surgery
Background:
- Carotid revascularization is crucial for stroke prevention in patients with carotid stenosis.
- Assessing cognitive impact post-intervention is vital for patient outcomes.
Purpose of the Study:
- To analyze the cognitive performance impact of carotid revascularization (CEA vs. CAS) after 3 months.
- To compare cognitive outcomes between carotid endarterectomy and carotid artery stenting.
Main Methods:
- Prospective, nonrandomized study of 30 patients with carotid stenosis.
- Patients underwent either carotid endarterectomy (CEA) or carotid artery stenting (CAS).
- Comprehensive neuropsychological evaluation included memory, attention, and executive function tests.
Main Results:
- Both CEA and CAS groups showed cognitive improvements, particularly in episodic memory.
- Carotid artery stenting (CAS) group demonstrated significant improvements in working memory and executive functions.
- CAS group achieved higher scores in executive functions compared to the CEA group.
Conclusions:
- Both carotid endarterectomy and carotid artery stenting positively impact cognitive function.
- Carotid artery stenting may offer superior benefits for executive function and operational memory/attention.

