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Related Concept Videos

Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

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Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
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After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
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Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
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Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

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Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
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Cells use energy-requiring bulk transport mechanisms to transfer large particles or large numbers of small particles into or out of the cell. The cells envelop the particles in spherical membranes called vesicles or vacuoles. Vesicles that transport material into the cell are built from the cell membrane. These vesicles encapsulate external molecules and transport them into the cell in a process called endocytosis.
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Pinocytosis00:43

Pinocytosis

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Cells use energy-requiring bulk transport mechanisms to transfer large particles, or large amounts of small particles, into or out of the cell. The cells envelop the particles in spherical membranes called vesicles or vacuoles. Vesicles that transport material into the cell are built from the cell membrane. These vesicles encapsulate external molecules and transport them into the cell in a process called endocytosis.
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Related Experiment Video

Updated: May 4, 2026

Generation and Quantitative Characterization of Functional and Polarized Biliary Epithelial Cysts
09:55

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A unique spontaneous subcapsular bilioma.

Ananta Shrestha1, Thupten Kelsang Lama1

  • 1Hepatology wing, Department of Medicine, Civil Service Hospital, Kathmandu, Nepal.

JNMA; Journal of the Nepal Medical Association
|December 24, 2013
PubMed
Summary

Spontaneous subcapsular bilioma, a rare bile collection, typically follows biliary trauma. This case highlights a unique instance occurring without known biliary issues, except for a single gallstone, questioning its classification.

Area of Science:

  • Hepatobiliary Surgery
  • Gastroenterology
  • Radiology

Background:

  • Spontaneous subcapsular bilioma is an uncommon extrabiliary collection of bile.
  • It typically arises secondary to biliary trauma or surgical interventions.
  • Occurrence in the absence of known biliary abnormalities is exceedingly rare.

Observation:

  • This report details a unique case of spontaneous subcapsular bilioma.
  • The patient presented with no prior history of biliary tract abnormalities.
  • The only identified biliary anomaly was a solitary gallstone.

Findings:

  • The case challenges the typical etiology of spontaneous subcapsular bilioma.
  • The presence of a solitary gallstone prompts re-evaluation of its classification.

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  • Discussion is initiated on whether this constitutes an idiopathic spontaneous variant.

    • Implications:

    • This finding may broaden the diagnostic criteria for spontaneous subcapsular bilioma.
    • It suggests that even minor biliary anomalies like a solitary gallstone could be implicated.
    • Further research is warranted to understand the pathogenesis and classification of such rare cases.