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Updated: May 4, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Effectiveness of early antibiotic administration in septic patients with cancer
B Parish1, T Cooksley2, P Haji-Michael3
1University of Manchester.
Introduction:
First dose intravenous antimicrobial therapy should be administered within 1 hour of admission but this is achieved in a minority of patients.
Methods:
We performed a retrospective analysis at the largest Oncology hospital in Europe. Nurse-led administration of initial antibiotic therapy was introduced to the admissions unit.
Results:
The nurse led protocol increased compliance with the 1 hour target from 40% to 88.6%. There was a statistically significant decrease in the mean length of stay (p=0.045) which was more pronounced in the neutropenic population (p=0.006). There was a trend to improved 30 day mortality.
Conclusions:
A nurse led protocol can be effective in improving compliance with the 1 hour target. Early administration of intravenous antibiotics in cancer patients with sepsis is associated with a shorter length of inpatient stay and a trend to decreased mortality.
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