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Peutz-Jeghers syndrome: quantitative study on enterochromaffin cells in hamartomatous intestine polyps

Miljan Krstić1, Vuka Katić2, Slavica Stojnev2

  • 1Department of Pathology, Faculty of Medicine, University of Nis, Nis, Serbia. krstic.miljan@gmail.com

Srpski Arhiv Za Celokupno Lekarstvo
|December 25, 2013
PubMed

Insights

Peutz-Jeghers (PJ) syndrome polyps show significantly increased enterochromaffin (EC) cells. This marked hyperplasia of EC cells in PJ polyps may cause functional disorders in affected patients.

Area of Science:

  • Gastroenterology
  • Oncology
  • Cell Biology

Background:

  • Peutz-Jeghers (PJ) syndrome is a rare autosomal disorder.
  • Characterized by intestinal polyps, pigmentation, and increased cancer risk.
  • Clinical issues may relate to serotonin secretion from enterochromaffin (EC) cells.

Purpose of the Study:

  • Quantitatively assess the EC cell population in PJ polyps.
  • Investigate EC cells in hamartomatous intestinal polyps.
  • Address the lack of prior data on EC cells in PJ polyps.

Main Methods:

  • Collected 21 PJ polyps over 34 years.
  • Used HE, AB-PAS, Van Gieson, Fontana-Masson, FIF, and Grimelius staining.
  • Performed immunohistochemistry for chromogranin A, serotonin, Ki-67, desmin, vimentin, and cytokeratin.

Main Results:

  • Observed significant EC cell hyperplasia in PJ polyps.
  • Demonstrated a higher EC cell content in PJ polyps versus normal ileal mucosa.
  • Confirmed diagnosis and ruled out differential diagnoses using markers.

Conclusions:

  • Marked EC cell hyperplasia is present in PJ polyps.
  • This hyperplasia may significantly contribute to functional disorders in PJ syndrome.
  • Highlights the role of EC cells in PJ syndrome pathophysiology.
Abstract

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