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Updated: May 4, 2026

Corneal Donor Tissue Preparation for Endothelial Keratoplasty
Published on: June 12, 2012
Prevention and Management of Microkeratome-related Laser in situ Keratomileusis Complications
Purpose:
To review the most commonly encountered laser in situ keratomileusis (LASIK) microkeratome-related complications, and the most up-to-date methods in their prevention and treatment.
Methods:
A review of microkeratome-related complications including epithelial complications, bleeding, thin flap, button hole, free cap, incomplete pass, and corneal perforation was conducted. The most recent techniques for prevention and treatment of each complication were included.
Results And Conclusion:
Microkeratome complications are difficult to predict. With proper attention to anatomical and mechanical considerations, many can be reduced or prevented. [J Refract Surg 2000;16(suppl):S226-S229].
Insights
Laser in situ keratomileusis (LASIK) microkeratome complications are unpredictable but preventable. Careful attention to anatomical and mechanical factors can reduce or avoid issues like thin flaps or corneal perforations.
Area of Science:
- Ophthalmology
- Refractive Surgery
Background:
- This review focuses on common microkeratome-related complications during laser in situ keratomileusis (LASIK).
- Complications include epithelial issues, bleeding, thin flaps, buttonholes, free caps, incomplete passes, and corneal perforations.
Discussion:
- The review examines the most current prevention and treatment strategies for each identified complication.
- Emphasis is placed on understanding the factors contributing to these adverse events.
Key Insights:
- Microkeratome complications are inherently difficult to predict.
- Many complications can be significantly reduced or entirely prevented through meticulous surgical planning and execution.
Outlook:
- Future advancements may offer improved predictability and further reduction in LASIK complications.
- Continued focus on anatomical and mechanical considerations is crucial for enhancing patient safety in refractive surgery.

