Related Experiment Video
Updated: Aug 16, 2025

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
The Use of a Multimodal Case Study To Illustrate Microbial Genetics, Metabolism, and Evolution: The Emergence of
N Boury1, M E D Van den Bogaard1, C Wasendorf1
1Plant Pathology and Micrology Department, Iowa State University, Ames, Iowa, USA.
Abstract:
Antibiotic Resistance (ABR) is a global concern and while many students are aware of this issue, many of them are unclear on the mechanisms by which ABR may emerge. The mechanism of horizontal gene transfer is something many students are not familiar with. In this curriculum contribution we present 2 versions of an 'interrupted case study' that is designed as an introduction to horizontal gene transfer for early major students and as a review case for advanced major students in biology and life sciences. The case is based on an authentic patient who developed infections with both methicillin resistant Staphylococcus aureus and vancomycin resistant S. aureus. The interrupted case study is appropriate for small and large groups and engages students while content is introduced in a highly structured way. This type of case study can be done by novice and seasoned instructors and lead to considerable learning gains in both introductory and intermediate microbiology courses.
Related Concept Videos
Modern Molecular Taxonomy
Mutations in Microorganisms
The Antiviral System of Bacteria and Archaea: CRISPR
Microbial Morphologies
Viruses of Archaea
Microbial Classification System

