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Dynamic mechanisms underlying afterdischarge: a human subdural recording study.

Giridhar P Kalamangalam1, Nitin Tandon2, Jeremy D Slater1

  • 1Department of Neurology, University of Texas Health Science Center, Houston, TX, USA.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|December 25, 2013
PubMed
Summary

Afterdischarges (ADs) result from synchronized brain activity, likely due to temporary inactivation of inhibitory interneurons. This study proposes a mechanism for AD emergence following cortical electrical stimulation.

Keywords:
Cortical stimulation mappingElectroencephalogramFourier analysisPartial epilepsyWeiner–Winfree–Kuramoto model

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Afterdischarges (ADs) are poorly understood phenomena following cortical electrical stimulation.
  • Existing knowledge lacks a unified mechanism explaining AD occurrence and characteristics.

Purpose of the Study:

  • To elucidate the mechanism behind the emergence and morphology of afterdischarges (ADs) in the cerebral cortex.
  • To develop phenomenological models for ADs based on human electrocorticogram (ECoG) data.

Main Methods:

  • Retrospective analysis of ECoG data from 15 epilepsy patients undergoing cortical stimulation mapping.
  • Spectral analysis of AD time-series and resting ECoG segments.

Main Results:

  • An analytical link was found between baseline ECoG spectra and subsequent ADs.
  • ADs are characterized by spectral 'condensation' of baseline activity, with potential inclusion of higher harmonics.

Conclusions:

  • ADs emerge from the synchronization of local field potentials, potentially via inhibitory interneuron inactivation.
  • Recurrent feedback, possibly from single-unit activity, modulates ADs, indicated by higher harmonics.