Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

12.0K
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
12.0K
Glial Cells01:04

Glial Cells

75.2K
Overview
75.2K
Neuron Structure01:30

Neuron Structure

18.1K
Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
18.1K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

2.1K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
2.1K
Neurulation01:30

Neurulation

40.2K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
40.2K
Nervous Tissue: Myelin01:25

Nervous Tissue: Myelin

12.1K
The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
12.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GABA shapes GBM immune responses in a sex-dependent manner.

Nature cancer·2026
Same author

Hp1bp3 loss links chromatin reorganization to metabolic vulnerability in glioma.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Nuclear export as a therapeutic vulnerability in ZFTA-RELA ependymoma.

Neuro-oncology·2026
Same author

Author Correction: Astrocytic Sox9 overexpression in Alzheimer's disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function.

Nature neuroscience·2026
Same author

Glo1 promotes glioma progression by modulating Sox2 transcriptional networks in glioma stem-like cells.

Neuro-oncology·2026
Same author

H3 dopaminylation and CaMKII modulate diffuse midline glioma response to CDK9 inhibition.

bioRxiv : the preprint server for biology·2026
Same journal

Concussion in contact sport: risks, detection, & prevention.

Seminars in pediatric neurology·2026
Same journal

A multidisciplinary, symptom-targeted approach to rehabilitation in pediatric concussion.

Seminars in pediatric neurology·2026
Same journal

Pediatric concussion beyond sports: Falls, play, and everyday activities.

Seminars in pediatric neurology·2026
Same journal

Return-to-school protocols in pediatric concussion care.

Seminars in pediatric neurology·2026
Same journal

Improving concussion recognition in youth sports: the role of parents, coaches, and community education.

Seminars in pediatric neurology·2026
Same journal

Concussion management, rehabilitation, and societal impact.

Seminars in pediatric neurology·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Isolation and Culture of Mouse Cortical Astrocytes
11:25

Isolation and Culture of Mouse Cortical Astrocytes

Published on: January 19, 2013

92.8K

Astrocyte form and function in the developing central nervous system.

Lesley S Chaboub1, Benjamin Deneen2

  • 1Program in Developmental Biology, Baylor College of Medicine, Houston, TX; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX.

Seminars in Pediatric Neurology
|December 25, 2013
PubMed
Summary
This summary is machine-generated.

Astrocytes, once overlooked, are now recognized as crucial in central nervous system (CNS) function and disease. Understanding astrocyte development offers potential therapeutic targets for pediatric neurologic disorders.

More Related Videos

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
08:52

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

13.8K
Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions
08:00

Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions

Published on: June 4, 2020

3.9K

Related Experiment Videos

Last Updated: May 4, 2026

Isolation and Culture of Mouse Cortical Astrocytes
11:25

Isolation and Culture of Mouse Cortical Astrocytes

Published on: January 19, 2013

92.8K
Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
08:52

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

13.8K
Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions
08:00

Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions

Published on: June 4, 2020

3.9K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Astrocytes were historically underestimated in understanding brain function.
  • Recent research highlights astrocytes' critical roles in central nervous system (CNS) physiology and disease.
  • Astrocyte dysregulation is increasingly linked to pediatric neurologic disorders such as leukodystrophies, autism spectrum disorders, and epilepsy.

Purpose of the Study:

  • To review the current knowledge of astrocyte development and function within the developing CNS.
  • To identify and discuss existing challenges and unanswered questions in the field of astrocyte development.
  • To explore the potential of astrocytes and their functions as therapeutic targets for neurologic disorders.

Main Methods:

  • Literature review and synthesis of existing research on astrocyte development and function.
  • Focus on the context of the developing central nervous system (CNS).
  • Identification of key pediatric neurologic disorders associated with astrocyte dysregulation.

Main Results:

  • Astrocytes are integral to CNS development and function.
  • Dysregulation of astrocytes is implicated in several pediatric neurological conditions.
  • Significant knowledge gaps remain regarding astrocyte development.

Conclusions:

  • Astrocytes are vital players in the developing CNS.
  • Further research into astrocyte development is crucial for understanding and treating pediatric neurologic disorders.
  • Targeting astrocyte development and function presents a promising avenue for novel therapeutic strategies.